Ingredients & Label Transparency Premium raw ingredients exclusively sourced from trusted suppliers who meet our rigorous testing and quality criteria Each ingredient and final product is independently tested for potency and purity Ingredients and allergens clearly listed on supplement facts label All two-piece capsules are hypoallergenic and vegetarian Manufacturing Manufactured locally in our own state-of-the-art facility in Sudbury, Massachusetts Our warehouse is climate controlled and each piece of equipment is dismantled and sterilized before every production run Every step of our manufacturing process exceeds the requirements for nutritional supplement manufacturing GMO Policy All Pure Encapsulations ingredients are GMO free.†  †All Pure Encapsulations ingredients, including those derived from corn, are GMO free. We obtain statements from each of our suppliers certifying that the ingredients do not contain GMOs. For some nutrients, we conduct testing to confirm the absence of genetically modified material.   Product Description Researchers at the the University of Texas M.D. Anderson Cancer Center, Memorial Sloan-Kettering Cancer Center of New York, AMC Cancer Center in Colorado, and Ohio State University have extensively studied d-glucarate. Calcium-d-Glucarate, a patented form of glucaric acid, is a powerful nutrient with the potential to support healthy detoxification and cellular function. In the liver, toxic compounds are bound to glucuronic acids so that they can be eliminated in a safe form from the body in a cleansing process known as glucuronidation. Beta-glucuronidase is a naturally-occurring enzyme found in various organs and cells, which can cleave apart these neutral compounds. d-Glucarate has been shown to help target beta-glucuronidase enzyme activity, supporting the process by which healthy cells eliminate waste and foreign elements. It also helps to maintain healthy cell structure and function. Other studies suggest the promising role of d-glucarate in supporting healthy lipid metabolism.